Post-Doctoral Scholar
University of Kentucky
Lexington, KY
Full-time
Education
Posted on April 22, 2024
Posting Details
Posting Details
Job Title
Post-Doctoral Scholar
Requisition Number
DU11360
Department Name
7H025:CANCER CENTER-CORE SUPPORT
Work Location
Lexington, KY
Salary Range
$56,484 - $63,852 (dependent upon years of svc)
Type of Position
Temporary
Position Time Status
Full-Time
Required Education
PhD or equivalent in Microbiology or related field
Required Related Experience
Molecular Biology RESEARCH: Cell culture, animal work, western blot, qPCR, IHC, ELISA
Required License/Registration/Certification
None
Physical Requirements
Sitting at computer work station for long periods of time, Standing for long periods of time, Repetitive motion, Hazardous Chemicals or fumes, Burns/Cuts/Punctures
Shift
Monday – Friday 8a-5p, occasional overtime, some weekends required
Job Summary
The Markey Cancer Center is seeking a Post-Doctoral Scholar. We have established the importance of neurotensin (NT), a gut hormone peptide, in obese development and its associated metabolic disorders. Obesity is associated with an increase in colorectal cancer ( CRC) incidence. We also found that NT regulates intestinal epithelial cells as well as intestinal stem cells ( ISC) in a manner dependent on the availability of nutrients. Under nutrient-rich conditions, NT promotes crypt cell proliferation. Under conditions of nutrient depletion, NT enhances ISC function. Obesity may rise intestinal carcinogenesis by increasing Intestinal ISC/progenitor's population, stemness, and niche. We will investigate whether NT regulates CRC carcinogenesis via ISC or their niche. In addition, we are also interested in studying whether NT regulates CRC stem cells (CSCs). The new postdoc. will perform the in vitro experiments including cell culture, western blot, qPCR, IHC or ELISA. He/or she will perform intestinal crypt isolation and 3D organoid culture, tumor spheroid culture from patients. He/or she will also work with mice, such as sacrificing mice and collecting tissues.
This position will have the potential for a fully on-site work arrangement.
IMPORTANT: Resumes and CVs cannot be substituted for a completed application. Incomplete applications could disqualify you from being considered for this position. If the information on your resume is not entered on the application, this will prevent us from being able to assess your education and experience when trying to determine a salary offer. To be considered you must fully complete the online application being sure to only put one (1) job title for each entry (multiple job titles for one employer must have separate entries), the # of hours worked per week and your ending salary. You will also be required to upload a Cover Letter, CV, PhD transcript and as specific request 1, a copy of your PhD diploma. Optionally, you can upload a writing sample.
To view our exceptional benefits, please visit https://www.uky.edu/hr/benefits.
Skills / Knowledge / Abilities
Microsoft Word, Excel, PowerPoint, Adobe photoshop, Endnote
Does this position have supervisory responsibilities?
No
Preferred Education/Experience
Work experience in Molecular biology.
Deadline to Apply
06/30/2024
University Community of Inclusion
The University of Kentucky is committed to a diverse and inclusive workforce by ensuring all our students, faculty, and staff work in an environment of openness and acceptance. We strive to foster a community where people of all backgrounds, identities, and perspectives can feel secure and welcome. We also value the well-being of each of our employees and are dedicated to creating a healthy place to work, learn and live. In the interest of maintaining a safe and healthy environment for our students, employees, patients and visitors the University of Kentucky is a Tobacco & Drug Free campus.
As an Equal Opportunity Employer, we strongly encourage veterans, individuals with disabilities, women, and all minorities to consider our employment opportunities.
Any candidate offered a position may be required to pass pre-employment screenings as mandated by University of Kentucky Human Resources. These screenings may include a national background check and/or drug screen.
Posting Specific Questions
Required fields are indicated with an asterisk (*).
Required Documents
Posting Details
Job Title
Post-Doctoral Scholar
Requisition Number
DU11360
Department Name
7H025:CANCER CENTER-CORE SUPPORT
Work Location
Lexington, KY
Salary Range
$56,484 - $63,852 (dependent upon years of svc)
Type of Position
Temporary
Position Time Status
Full-Time
Required Education
PhD or equivalent in Microbiology or related field
Required Related Experience
Molecular Biology RESEARCH: Cell culture, animal work, western blot, qPCR, IHC, ELISA
Required License/Registration/Certification
None
Physical Requirements
Sitting at computer work station for long periods of time, Standing for long periods of time, Repetitive motion, Hazardous Chemicals or fumes, Burns/Cuts/Punctures
Shift
Monday – Friday 8a-5p, occasional overtime, some weekends required
Job Summary
The Markey Cancer Center is seeking a Post-Doctoral Scholar. We have established the importance of neurotensin (NT), a gut hormone peptide, in obese development and its associated metabolic disorders. Obesity is associated with an increase in colorectal cancer ( CRC) incidence. We also found that NT regulates intestinal epithelial cells as well as intestinal stem cells ( ISC) in a manner dependent on the availability of nutrients. Under nutrient-rich conditions, NT promotes crypt cell proliferation. Under conditions of nutrient depletion, NT enhances ISC function. Obesity may rise intestinal carcinogenesis by increasing Intestinal ISC/progenitor's population, stemness, and niche. We will investigate whether NT regulates CRC carcinogenesis via ISC or their niche. In addition, we are also interested in studying whether NT regulates CRC stem cells (CSCs). The new postdoc. will perform the in vitro experiments including cell culture, western blot, qPCR, IHC or ELISA. He/or she will perform intestinal crypt isolation and 3D organoid culture, tumor spheroid culture from patients. He/or she will also work with mice, such as sacrificing mice and collecting tissues.
This position will have the potential for a fully on-site work arrangement.
IMPORTANT: Resumes and CVs cannot be substituted for a completed application. Incomplete applications could disqualify you from being considered for this position. If the information on your resume is not entered on the application, this will prevent us from being able to assess your education and experience when trying to determine a salary offer. To be considered you must fully complete the online application being sure to only put one (1) job title for each entry (multiple job titles for one employer must have separate entries), the # of hours worked per week and your ending salary. You will also be required to upload a Cover Letter, CV, PhD transcript and as specific request 1, a copy of your PhD diploma. Optionally, you can upload a writing sample.
To view our exceptional benefits, please visit https://www.uky.edu/hr/benefits.
Skills / Knowledge / Abilities
Microsoft Word, Excel, PowerPoint, Adobe photoshop, Endnote
Does this position have supervisory responsibilities?
No
Preferred Education/Experience
Work experience in Molecular biology.
Deadline to Apply
06/30/2024
University Community of Inclusion
The University of Kentucky is committed to a diverse and inclusive workforce by ensuring all our students, faculty, and staff work in an environment of openness and acceptance. We strive to foster a community where people of all backgrounds, identities, and perspectives can feel secure and welcome. We also value the well-being of each of our employees and are dedicated to creating a healthy place to work, learn and live. In the interest of maintaining a safe and healthy environment for our students, employees, patients and visitors the University of Kentucky is a Tobacco & Drug Free campus.
As an Equal Opportunity Employer, we strongly encourage veterans, individuals with disabilities, women, and all minorities to consider our employment opportunities.
Any candidate offered a position may be required to pass pre-employment screenings as mandated by University of Kentucky Human Resources. These screenings may include a national background check and/or drug screen.
Posting Specific Questions
Required fields are indicated with an asterisk (*).
Required Documents
- Curriculum Vita
- Writing Sample
- Academic Transcript
- Specific Request 1
